Clusters of microcalcifications and breast cancer

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Background Recent comparative studies have demonstrated several advantages of minimally invasive breast biopsy procedures over needle localization core surgical biopsy NLBx. Minimally invasive breast biopsy procedures take less time to perform than NLBx, cause less patient discomfort and cosmetic deformity, result in less artifact on subsequent mammography, and are more cost effective. If a benign lesion is found, the patient can be followed with clinical examinations and mammography and an open surgical procedure is avoided. Biopsies can be obtained either with a fine-needle gauge or large bore and gauge needle. However, the large-core biopsy is favored over fine-needle biopsy for several reasons:
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Potentially Malignant microcalcification by texture

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Breast Microcalcifications on mammogram - Moose and Doc

The TDLU consists of acini, that drain into the terminal duct. The terminal duct drains into larger ducts and finally into the main duct of the lobe or segment , that drains into the nipple. The breast contains lobes, that each contain lobules. The terminal ductal lobular unit is an important structure because most invasive cancers arise from the TDLU. It also is the site of origin of ductal carcinoma in situ DCIS , lobular carcinoma in situ, fibroadenoma and fibrocystic disease, like cysts, apocine metaplasia, adenosis and epitheliosis. Most calcifications in the breast form either within the terminal ducts intraductal calcifications or within the acini lobular calcifications.
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Breast microcalcifications on mammogram

Classifications of Breast Microcalcifications according to form, size, density, and distribution. So, they can be round, linear, coarse, granular fine , monomorphic all the same basic shape , or pleomorphic many different shapes. Also, breast microcalcifications can form in clusters, or groups. In Size, specialists describe breast microcalfications as either large or small, or when in clusters whether the sizes of microcalcifications are homogeneous or not.
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The most frequent clinical application of breast ultrasonography is to characterize masses initially detected by mammography as cystic or solid. Cysts are lined by apocrine cells that actively secrete material, predisposing these types of cysts to recur after aspiration. Sometimes, cysts are lined by a flat epithelial lining that is less active.
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